Accurate forecasts of infections for localized regions are valuable for policy making and medical capacity planning. Existing compartmental and agent-based models for epidemiological forecasting employ static parameter choices and cannot be readily contextualized, while adaptive solutions focus primarily on the reproduction number. The current work proposes a novel model-agnostic Bayesian optimization approach for learning model parameters from observed data that generalizes to multiple application-specific fidelity criteria. Empirical results point to the efficacy of the proposed method with SEIR-like models on COVID-19 case forecasting tasks. A city-level forecasting system based on this method is being used for COVID-19 response in a few impacted Indian cities.
